Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages

Efferocytosis is critical for tissue homeostasis, as its deregulation is associated with several autoimmune pathologies. While engulfing apoptotic cells, phagocytes activate transcription factors, such as peroxisome proliferator-activated receptors (PPAR) or liver X receptors (LXR) that orchestrate...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Mota, Ana Carolina, Dominguez, Monica, Weigert, Andreas, Snodgrass, Ryan G., Namgaladze, Dmitry, Brüne, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137840/
https://ncbi.nlm.nih.gov/pubmed/34025647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.637778
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