AMP-activated Protein Kinase Suppresses Arachidonate 15-Lipoxygenase Expression in Interleukin 4-polarized Human Macrophages

Macrophages respond to the Th2 cytokine IL-4 with elevated expression of arachidonate 15-lipoxygenase (ALOX15). Although IL-4 signaling elicits anti-inflammatory responses, 15-lipoxygenase may either support or inhibit inflammatory processes in a context-dependent manner. AMP-activated protein kinas...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Namgaladze, Dmitry, Snodgrass, Ryan G., Angioni, Carlo, Grossmann, Nina, Dehne, Nathalie, Geisslinger, Gerd, Brüne, Bernhard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2015
Konular:
Immunology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591829/
https://ncbi.nlm.nih.gov/pubmed/26276392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678243
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