The miR-181a-SFRP4 axis regulates Wnt activation to drive stemness and platinum resistance in ovarian cancer

Wnt signaling is a major driver of stemness and chemo-resistance in ovarian cancer, yet the genetic drivers that stimulate its expression remain largely unknown. Unlike other cancers, mutations in the Wnt pathway are not reported in high-grade serous ovarian cancer (HGSOC). Hence, a key challenge th...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Nagaraj, Anil Belur, Knarr, Matthew, Sekhar, Sreeja, Connor, R. Shae, Joseph, Peronne, Kovalenko, Olga, Fleming, Alexis, Surti, Arshia, Nurmemmedov, Elmar, Beltrame, Luca, Marchini, Sergio, Kahn, Michael, DiFeo, Analisa
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137569/
https://ncbi.nlm.nih.gov/pubmed/33574092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2041
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