Therapeutic targeting of DGKA-mediated macropinocytosis leads to phospholipid reprogramming in Tuberous Sclerosis Complex

Lymphangioleiomyomatosis (LAM) is a rare destructive lung disease affecting primarily women and is the primary lung manifestation of tuberous sclerosis complex (TSC). In LAM, biallelic loss of TSC1/2 leads to hyperactivation of mTORC1 and inhibition of autophagy. To determine how the metabolic vulne...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Kovalenko, Andrii, Sanin, Andres, Kosmas, Kosmas, Zhang, Long, Wang, Ji, Akl, Elie W., Giannikou, Krinio, Probst, Clemens K., Hougard, Thomas R., Rue, Ryan W., Krymskaya, Vera P., Asara, John M., Lam, Hilaire C., Kwiatkowski, David J., Henske, Elizabeth P., Filippakis, Harilaos
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137542/
https://ncbi.nlm.nih.gov/pubmed/33593821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2218
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