Therapeutic targeting of DGKA-mediated macropinocytosis leads to phospholipid reprogramming in Tuberous Sclerosis Complex

Lymphangioleiomyomatosis (LAM) is a rare destructive lung disease affecting primarily women and is the primary lung manifestation of tuberous sclerosis complex (TSC). In LAM, biallelic loss of TSC1/2 leads to hyperactivation of mTORC1 and inhibition of autophagy. To determine how the metabolic vulne...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Kovalenko, Andrii, Sanin, Andres, Kosmas, Kosmas, Zhang, Long, Wang, Ji, Akl, Elie W., Giannikou, Krinio, Probst, Clemens K., Hougard, Thomas R., Rue, Ryan W., Krymskaya, Vera P., Asara, John M., Lam, Hilaire C., Kwiatkowski, David J., Henske, Elizabeth P., Filippakis, Harilaos
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137542/
https://ncbi.nlm.nih.gov/pubmed/33593821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2218
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