Therapeutic targeting of DGKA-mediated macropinocytosis leads to phospholipid reprogramming in Tuberous Sclerosis Complex

Lymphangioleiomyomatosis (LAM) is a rare destructive lung disease affecting primarily women and is the primary lung manifestation of tuberous sclerosis complex (TSC). In LAM, biallelic loss of TSC1/2 leads to hyperactivation of mTORC1 and inhibition of autophagy. To determine how the metabolic vulne...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Kovalenko, Andrii, Sanin, Andres, Kosmas, Kosmas, Zhang, Long, Wang, Ji, Akl, Elie W., Giannikou, Krinio, Probst, Clemens K., Hougard, Thomas R., Rue, Ryan W., Krymskaya, Vera P., Asara, John M., Lam, Hilaire C., Kwiatkowski, David J., Henske, Elizabeth P., Filippakis, Harilaos
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137542/
https://ncbi.nlm.nih.gov/pubmed/33593821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2218
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