Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

Gene activator proteins comprise distinct DNA-binding and transcriptional activation domains (ADs). Because few ADs have been described, we tested domains tiling all yeast transcription factors for activation in vivo and identified 150 ADs. By mRNA display, we showed that 73% of ADs bound the Med15...

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Vydáno v:eLife
Hlavní autoři: Sanborn, Adrian L, Yeh, Benjamin T, Feigerle, Jordan T, Hao, Cynthia V, Townshend, Raphael JL, Lieberman Aiden, Erez, Dror, Ron O, Kornberg, Roger D
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2021
Témata:
Chromosomes and Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137143/
https://ncbi.nlm.nih.gov/pubmed/33904398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.68068
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