Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

Gene activator proteins comprise distinct DNA-binding and transcriptional activation domains (ADs). Because few ADs have been described, we tested domains tiling all yeast transcription factors for activation in vivo and identified 150 ADs. By mRNA display, we showed that 73% of ADs bound the Med15...

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Publicat a:eLife
Autors principals: Sanborn, Adrian L, Yeh, Benjamin T, Feigerle, Jordan T, Hao, Cynthia V, Townshend, Raphael JL, Lieberman Aiden, Erez, Dror, Ron O, Kornberg, Roger D
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2021
Matèries:
Chromosomes and Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137143/
https://ncbi.nlm.nih.gov/pubmed/33904398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.68068
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