Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever

Importing necessary metabolites into the mitochondrial matrix is a crucial step of fuel choice during stress adaptation. Branched chain-amino acids (BCAAs) are essential amino acids needed for anabolic processes, but they are also imported into the mitochondria for catabolic reactions. What controls...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Yoneshiro, Takeshi, Kataoka, Naoya, Walejko, Jacquelyn M, Ikeda, Kenji, Brown, Zachary, Yoneshiro, Momoko, Crown, Scott B, Osawa, Tsuyoshi, Sakai, Juro, McGarrah, Robert W, White, Phillip J, Nakamura, Kazuhiro, Kajimura, Shingo
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2021
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137140/
https://ncbi.nlm.nih.gov/pubmed/33944778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66865
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