BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

Branched-chain amino acid (BCAA; valine, leucine, and isoleucine) supplementation is often beneficial to energy expenditure; however, paradoxically increased circulating BCAA levels are linked to obesity and diabetes. The mechanisms of the paradox remain elusive. Here we report that, upon cold expos...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Yoneshiro, Takeshi, Wang, Qiang, Tajima, Kazuki, Matsushita, Mami, Maki, Hiroko, Igarashi, Kaori, Dai, Zhipeng, White, Phillip J., McGarrah, Robert W., Ilkayeva, Olga R, Deleye, Yann, Oguri, Yasuo, Kuroda, Mito, Ikeda, Kenji, Li, Huixia, Ueno, Ayano, Ohishi, Maki, Ishikawa, Takamasa, Kim, Kyeongkyu, Chen, Yong, Sponton, Carlos Henrique, Pradhan, Rachana N., Majd, Homa, Greiner, Vanille Juliette, Yoneshiro, Momoko, Brown, Zachary, Chondronikola, Maria, Takahashi, Haruya, Goto, Tsuyoshi, Kawada, Teruo, Sidossis, Labros, Szoka, Francis C., McManus, Michael T., Saito, Masayuki, Soga, Tomoyoshi, Kajimura, Shingo
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715529/
https://ncbi.nlm.nih.gov/pubmed/31435015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1503-x
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