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Endogenous p53 expression in human and mouse is not regulated by its 3′UTR

The TP53 gene encodes the tumor suppressor p53 which is functionally inactivated in many human cancers. Numerous studies suggested that 3′UTR-mediated p53 expression regulation plays a role in tumorigenesis and could be exploited for therapeutic purposes. However, these studies did not investigate p...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Mitschka, Sibylle, Mayr, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137139/
https://ncbi.nlm.nih.gov/pubmed/33955355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65700
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