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Endogenous p53 expression in human and mouse is not regulated by its 3′UTR

The TP53 gene encodes the tumor suppressor p53 which is functionally inactivated in many human cancers. Numerous studies suggested that 3′UTR-mediated p53 expression regulation plays a role in tumorigenesis and could be exploited for therapeutic purposes. However, these studies did not investigate p...

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Publicat a:eLife
Autors principals: Mitschka, Sibylle, Mayr, Christine
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137139/
https://ncbi.nlm.nih.gov/pubmed/33955355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65700
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