Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization

High(er) throughput toxicokinetics (HTTK) encompasses in vitro measures of key determinants of chemical toxicokinetics and reverse dosimetry approaches for in vitro-in vivo extrapolation (IVIVE). With HTTK, the bioactivity identified by any in vitro assay can be converted to human equivalent doses a...

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Publicat a:Toxicol Sci
Autors principals: Wambaugh, John F., Wetmore, Barbara A., Ring, Caroline L., Nicolas, Chantel I., Pearce, Robert, Honda, Gregory, Dinallo, Roger, Angus, Derek, Gilbert, Jon, Sierra, Teresa, Badrinarayanan, Akshay, Snodgrass, Bradley, Brockman, Adam, Strock, Chris, Setzer, Woodrow, Thomas, Russell S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8136471/
https://ncbi.nlm.nih.gov/pubmed/31532498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz205
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