Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization

High(er) throughput toxicokinetics (HTTK) encompasses in vitro measures of key determinants of chemical toxicokinetics and reverse dosimetry approaches for in vitro-in vivo extrapolation (IVIVE). With HTTK, the bioactivity identified by any in vitro assay can be converted to human equivalent doses a...

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Pubblicato in:Toxicol Sci
Autori principali: Wambaugh, John F., Wetmore, Barbara A., Ring, Caroline L., Nicolas, Chantel I., Pearce, Robert, Honda, Gregory, Dinallo, Roger, Angus, Derek, Gilbert, Jon, Sierra, Teresa, Badrinarayanan, Akshay, Snodgrass, Bradley, Brockman, Adam, Strock, Chris, Setzer, Woodrow, Thomas, Russell S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8136471/
https://ncbi.nlm.nih.gov/pubmed/31532498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz205
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