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Septin 4 activates PPARγ/LXRα signaling by upregulating ABCA1 and ABCG1 expression to inhibit the formation of THP-1 macrophage-derived foam cells

Septin 4 is a member of a family of GTP-binding proteins that has been previously reported regulate cytoskeletal organization. In addition, it has been suggested to serve a role in atherosclerosis. Therefore, the present study aimed to investigate the effects of Septin 4 on foam cell formation. THP-...

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Bibliografiske detaljer
Udgivet i:Exp Ther Med
Main Authors: Song, Xiaoying, Yan, Guoliang, Wang, Haihui, Lou, Danfei
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135116/
https://ncbi.nlm.nih.gov/pubmed/34035860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2021.10195
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