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Pharmacokinetics and safety of TCMCB07, a melanocortin‐4 antagonist peptide in dogs

The melanocortin‐4 receptor (MC4R) antagonistic peptide TCMCB07 was developed for the treatment of cachexia. The objectives of this study were to examine pharmacokinetics and safety of TCMCB07 administered subcutaneously to healthy dogs. Dogs were treated with high‐ (2.25 mg kg(−1)) (n = 5) and low‐...

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Bibliografske podrobnosti
izdano v:Pharmacol Res Perspect
Main Authors: Axiak‐Bechtel, Sandra M., Leach, Stacey B., Scholten, David G., Newton‐Northup, Jessica R., Johnson, Brendan J., Durham, H. E., Gruber, Kenneth A., Callahan, Michael F.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135083/
https://ncbi.nlm.nih.gov/pubmed/34014033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.777
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