Proteasome Inhibition Suppresses KIT-Independent Gastrointestinal Stromal Tumors Via Targeting Hippo/YAP/Cyclin D1 Signaling

Purpose: Gastrointestinal stromal tumors (GISTs) are the most common malignant tumor of mesenchymal origin of the digestive tract. A yet more challenging resistance mechanism involves transition from oncogenic KIT to a new imatinib-insensitive oncogenic driver, heralded by loss of KIT expression. Ou...

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Publicat a:Front Pharmacol
Autors principals: Chen, Ting, Ni, Nan, Yuan, Li, Xu, Liangliang, Bahri, Nacef, Sun, Boshu, Wu, Yuehong, Ou, Wen-Bin
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134732/
https://ncbi.nlm.nih.gov/pubmed/34025442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.686874
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