High BRAF variant allele frequencies are associated with distinct pathological features and responsiveness to target therapy in melanoma patients

BACKGROUND: BRAF mutant melanoma patients are commonly treated with anti-BRAF therapeutic strategies. However, many factors, including the percentage of BRAF-mutated cells, may contribute to the great variability in patient outcomes. PATIENTS AND METHODS: The BRAF variant allele frequency (VAF; defi...

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Detalhes bibliográficos
Publicado no:ESMO Open
Main Authors: Berrino, E., Balsamo, A., Pisacane, A., Gallo, S., Becco, P., Miglio, U., Caravelli, D., Poletto, S., Paruzzo, L., Debernardi, C., Piccinelli, C., Zaccagna, A., Rescigno, P., Aglietta, M., Sapino, A., Carnevale-Schianca, F., Venesio, T.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134716/
https://ncbi.nlm.nih.gov/pubmed/33984673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.esmoop.2021.100133
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