Cold Formalin Fixation Guarantees DNA Integrity in Formalin Fixed Paraffin Embedded Tissues: Premises for a Better Quality of Diagnostic and Experimental Pathology With a Specific Impact on Breast Cancer

Formalin fixation and paraffin embedding (FFPE) represent the standard method to preserve tissue specimens for diagnostic pathology, however formalin fixation induces severe fragmentation of nucleic acids. We investigated whether formalin fixation at 4°C could preserve DNA integrity in FFPE specimen...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Berrino, Enrico, Annaratone, Laura, Miglio, Umberto, Maldi, Elena, Piccinelli, Chiara, Peano, Erica, Balmativola, Davide, Cassoni, Paola, Pisacane, Alberto, Sarotto, Ivana, Venesio, Tiziana, Sapino, Anna, Marchiò, Caterina
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042205/
https://ncbi.nlm.nih.gov/pubmed/32140450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00173
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