DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift

Culture expansion of primary cells evokes highly reproducible DNA methylation (DNAm) changes. We have identified CG dinucleotides (CpGs) that become continuously hyper- or hypomethylated during long-term culture of mesenchymal stem cells (MSCs) and other cell types. Bisulfite barcoded amplicon seque...

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Bibliografiske detaljer
Udgivet i:Commun Biol
Main Authors: Franzen, Julia, Georgomanolis, Theodoros, Selich, Anton, Kuo, Chao-Chung, Stöger, Reinhard, Brant, Lilija, Mulabdić, Melita Sara, Fernandez-Rebollo, Eduardo, Grezella, Clara, Ostrowska, Alina, Begemann, Matthias, Nikolić, Miloš, Rath, Björn, Ho, Anthony D., Rothe, Michael, Schambach, Axel, Papantonis, Argyris, Wagner, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134454/
https://ncbi.nlm.nih.gov/pubmed/34011964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02116-y
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