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Senescence‐associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells

Replicative senescence has a major impact on function and integrity of cell preparations. This process is reflected by continuous DNA methylation (DNAm) changes at specific CpG dinucleotides in the course of in vitro culture, and such modifications can be used to estimate the state of cellular senes...

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Detalles Bibliográficos
Publicado en:Aging Cell
Main Authors: Franzen, Julia, Zirkel, Anne, Blake, Jonathon, Rath, Björn, Benes, Vladimir, Papantonis, Argyris, Wagner, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242294/
https://ncbi.nlm.nih.gov/pubmed/27785870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12544
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