Insight into the drug resistance mechanisms of GS-9669 caused by mutations of HCV NS5B polymerase via molecular simulation

GS-9669 is a non-nucleos(t)ide inhibitor (NNI) binding to the thumb site II of the Hepatitis C virus (HCV) NS5B polymerase and has advanced into phase II trials. To clarify the drug resistance mechanisms of GS-9669 caused by M423T/I/V, L419M, R422K, and I482L mutations of NS5B polymerase (GT1b) and...

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Pubblicato in:Comput Struct Biotechnol J
Autori principali: Han, Di, Wang, Huiqun, Wujieti, Baerlike, Zhang, Beibei, Cui, Wei, Chen, Bo-Zhen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Research Network of Computational and Structural Biotechnology 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134009/
https://ncbi.nlm.nih.gov/pubmed/34093991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.04.026
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