Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice

Dysregulated glucagon secretion deteriorates glycemic control in type 1 and type 2 diabetes. Although insulin is known to regulate glucagon secretion via its cognate receptor (insulin receptor, INSR) in pancreatic alpha cells, the role of downstream proteins and signaling pathways underlying insulin...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Takatani, Tomozumi, Shirakawa, Jun, Shibue, Kimitaka, Gupta, Manoj K., Kim, Hyunki, Lu, Shusheng, Hu, Jiang, White, Morris F., Kennedy, Robert T., Kulkarni, Rohit N.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131928/
https://ncbi.nlm.nih.gov/pubmed/33839150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100646
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