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Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly

Topoisomerase II (topo II) is one of the six proteins essential for mitotic chromatid reconstitution in vitro. It is not fully understood, however, mechanistically how this enzyme regulates this process. In an attempt to further refine the reconstitution assay, we have found that chromosomal binding...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Shintomi, Keishi, Hirano, Tatsuya
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131626/
https://ncbi.nlm.nih.gov/pubmed/34006877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23205-w
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