High glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes

Diabetes (DB) is a risk factor for osteoarthritis progression. High glucose (HG) is one of the key pathological features of DB and has been demonstrated to induce apoptosis and senescence in chondrocytes. Autophagy is an endogenous mechanism that can protect cells against apoptosis and senescence. T...

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Опубликовано в: :Cell Death Dis
Главные авторы: Wang, Ben, Shi, Yifeng, Chen, Jiaoxiang, Shao, Zhenxuan, Ni, Libin, Lin, Yan, Wu, Yaosen, Tian, Naifeng, Zhou, Yifei, Sun, Liaojun, Wu, Aimin, Hong, Zhenghua, Wang, Xiangyang, Zhang, Xiaolei
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131591/
https://ncbi.nlm.nih.gov/pubmed/34006821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03791-9
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