Glycolytic ATP Fuels Phosphoinositide 3-Kinase Signaling to Support Effector T Helper 17 Cell Responses

Aerobic glycolysis - the Warburg effect - converts glucose to lactate via the enzyme LDHA and is a metabolic feature of effector T cells. Cells generate ATP through various mechanisms and Warburg metabolism is comparatively an energy-inefficient glucose catabolism pathway. Here, we examined the impa...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Xu, Ke, Yin, Na, Peng, Min, Stamatiades, Efstathios G., Chhangawala, Sagar, Shyu, Amy, Li, Peng, Zhang, Xian, Do, Mytrang H., Capistrano, Kristelle J., Chou, Chun, Leslie, Christina S., Li, Ming O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8130647/
https://ncbi.nlm.nih.gov/pubmed/33979589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.04.008
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