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Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

Aerobic glycolysis (the Warburg effect) is a metabolic hallmark of activated T cells, and has been implicated in augmenting effector T cell responses including expression of the pro-inflammatory cytokine interferon (IFN)-γ via 3′ untranslated region (3′UTR)-mediated mechanisms. Here we show that lac...

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Publicat a:Science
Autors principals: Peng, Min, Yin, Na, Chhangawala, Sagar, Xu, Ke, Leslie, Christina S., Li, Ming O.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539971/
https://ncbi.nlm.nih.gov/pubmed/27708054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf6284
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