SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis

Mitochondrial metabolism is the key source for abundant ROS in chronic lymphocytic leukemia (CLL) cells. Here, we detected significantly lower superoxide anion (O(2)(−)) levels with increased accumulation of hydrogen peroxide (H(2)O(2)) in CLL cells vs. normal B-cells. Further analysis indicated tha...

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發表在:Blood Cancer J
Main Authors: Maiti, Guru P., Sinha, Sutapa, Mahmud, Hasan, Boysen, Justin, Mendez, Mariana T., Vesely, Sara K., Holter-Chakrabarty, Jennifer, Kay, Neil E., Ghosh, Asish K.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129117/
https://ncbi.nlm.nih.gov/pubmed/34001853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-021-00484-6
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