SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis

Mitochondrial metabolism is the key source for abundant ROS in chronic lymphocytic leukemia (CLL) cells. Here, we detected significantly lower superoxide anion (O(2)(−)) levels with increased accumulation of hydrogen peroxide (H(2)O(2)) in CLL cells vs. normal B-cells. Further analysis indicated tha...

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Udgivet i:Blood Cancer J
Main Authors: Maiti, Guru P., Sinha, Sutapa, Mahmud, Hasan, Boysen, Justin, Mendez, Mariana T., Vesely, Sara K., Holter-Chakrabarty, Jennifer, Kay, Neil E., Ghosh, Asish K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129117/
https://ncbi.nlm.nih.gov/pubmed/34001853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-021-00484-6
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