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Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria

The speed of mRNA translation depends in part on the amino acid to be incorporated into the nascent chain. Peptide bond formation is especially slow with proline and two adjacent prolines can even cause ribosome stalling. While previous studies focused on how the amino acid context of a Pro-Pro moti...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Krafczyk, Ralph, Qi, Fei, Sieber, Alina, Mehler, Judith, Jung, Kirsten, Frishman, Dmitrij, Lassak, Jürgen
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8129111/
https://ncbi.nlm.nih.gov/pubmed/34002016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02115-z
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