Structure-activity mapping of ARHGAP36 reveals regulatory roles for its GAP homology and C-terminal domains

ARHGAP36 is an atypical Rho GTPase-activating protein (GAP) family member that drives both spinal cord development and tumorigenesis, acting in part through an N-terminal motif that suppresses protein kinase A and activates Gli transcription factors. ARHGAP36 also contains isoform-specific N-termina...

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Publicat a:PLoS One
Autors principals: Nano, Patricia R., Johnson, Taylor K., Kudo, Takamasa, Mooney, Nancie A., Ni, Jun, Demeter, Janos, Jackson, Peter K., Chen, James K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8128262/
https://ncbi.nlm.nih.gov/pubmed/33999959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0251684
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