DZNep, an inhibitor of the histone methyltransferase EZH2, suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 pathway

BACKGROUND: Hepatic fibrosis is a common response to chronic liver injury. Recently, the role of DZNep (a histone methyltransferase EZH2 inhibitor) in repressing pulmonary and renal fibrosis was verified. However, the potential effect of DZNep on hepatic fibrosis has not been elucidated. METHODS: Th...

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Detaylı Bibliyografya
Yayımlandı:PeerJ
Asıl Yazarlar: Ding, Rongrong, Zheng, Jianming, Li, Ning, Cheng, Qi, Zhu, Mengqi, Wang, Yanbing, Zhou, Xinlan, Zhang, Zhanqing, Shi, Guangfeng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: PeerJ Inc. 2021
Konular:
Biochemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127960/
https://ncbi.nlm.nih.gov/pubmed/34040893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.11374
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