3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells

OBJECTIVE: Growing evidences indicate that the histone methyltransferase EZH2 (enhancer of zeste homolog 2) may be an appropriate therapeutic target in some tumors. Indeed, a high expression of EZH2 is correlated with poor prognosis and metastasis in many cancers. In addition, 3-Deazaneplanocin A (D...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Girard, Nicolas, Bazille, Céline, Lhuissier, Eva, Benateau, Hervé, Llombart-Bosch, Antonio, Boumediene, Karim, Bauge, Catherine
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031152/
https://ncbi.nlm.nih.gov/pubmed/24852755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098176
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