Anti-inflammatory and chondroprotective effects of the S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin A, in human articular chondrocytes

3-Deazaneplanocin A (DZNep) is an inhibitor of S-Adenosyl-L-Homocysteine Hydrolase (SAHH) known to inhibit EZH2, a histone methylase upregulated during osteoarthritis. In this study, we assessed its effects in human articular chondrocytes. Anti-inflammatory effects were assessed by Nitric Oxide (NO)...

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Vydáno v:Sci Rep
Hlavní autoři: Aury-Landas, Juliette, Bazille, Céline, Allas, Lyess, Bouhout, Sara, Chesneau, Christophe, Leclercq, Sylvain, Boumédiene, Karim, Baugé, Catherine
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526903/
https://ncbi.nlm.nih.gov/pubmed/28744016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06913-6
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