Deacylcortivazol-like pyrazole regioisomers reveal a more accommodating expanded binding pocket for the glucocorticoid receptor

Glucocorticoids (GCs) are widely used, potent anti-inflammatory and chemotherapeutic drugs. They work by binding to the glucocorticoid receptor (GR), a ligand-activated transcription factor, inducing translocation to the nucleus and regulation of genes that influence a variety of cellular activities...

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Bibliografiska uppgifter
I publikationen:RSC Med Chem
Huvudupphovsmän: Zimmerman, Jessica A. O., Fang, Mimi, Doumbia, Bintou, Neyman, Alexis, Cha, Ji Hyeon, Thomas, Michael, Hall, Bonnie, Wu, Meng, Wilson, Anne M., Pufall, Miles A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: RSC 2020
Ämnen:
Chemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127617/
https://ncbi.nlm.nih.gov/pubmed/34046609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00278j
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