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Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol
A common feature of nuclear receptor ligand binding domains (LBD) is a helical sandwich fold that nests a ligand binding pocket within the bottom half of the domain. Here we report that the ligand pocket of glucocorticoid receptor (GR) can be continuously extended into the top half of the LBD by bin...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268401/ https://ncbi.nlm.nih.gov/pubmed/18160712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01541-07 |
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