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Ligand binding domain mutations of glucocorticoid receptor selectively modify effects with, but not binding of, cofactors
We previously reported that several point mutations in the ligand binding domain (LBD) of glucocorticoid receptors (GRs) marginally affect the binding affinity of the synthetic glucocorticoids dexamethasone (Dex) and deacylcortivazol (DAC). However, these mutations dramatically alter the efficacy (A...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3123670/ https://ncbi.nlm.nih.gov/pubmed/21142156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101792d |
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