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Ligand binding domain mutations of glucocorticoid receptor selectively modify effects with, but not binding of, cofactors

We previously reported that several point mutations in the ligand binding domain (LBD) of glucocorticoid receptors (GRs) marginally affect the binding affinity of the synthetic glucocorticoids dexamethasone (Dex) and deacylcortivazol (DAC). However, these mutations dramatically alter the efficacy (A...

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Main Authors: Lee, Geun-Shik, Simons, S. Stoney
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123670/
https://ncbi.nlm.nih.gov/pubmed/21142156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101792d
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