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A Natural Mutation in Helix 5 of the Ligand Binding Domain of Glucocorticoid Receptor Enhances Receptor-Ligand Interaction

The glucocorticoid receptor (GR) is a central player in the neuroendocrine stress response; it mediates feedback regulation of the hypothalamus-pituitary-adrenal (HPA) axis and physiological actions of glucocorticoids in the periphery. Despite intensive investigations of GR in the context of recepto...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Reyer, Henry, Ponsuksili, Siriluck, Kanitz, Ellen, Pöhland, Ralf, Wimmers, Klaus, Murani, Eduard
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063400/
https://ncbi.nlm.nih.gov/pubmed/27736993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164628
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