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A naturally hypersensitive glucocorticoid receptor elicits a compensatory reduction of hypothalamus–pituitary–adrenal axis activity early in ontogeny
We comprehensively characterized the effects of a unique natural gain-of-function mutation in the glucocorticoid receptor (GR), GR(Ala610Val), in domestic pigs to expand current knowledge of the phenotypic consequences of GR hypersensitivity. Cortisol levels were consistently reduced in one-week-old...
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| Publicado no: | Open Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4967818/ https://ncbi.nlm.nih.gov/pubmed/27440422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.150193 |
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