Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

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Detalhes bibliográficos
Publicado no:RSC Med Chem
Main Authors: Goddard, Zoë Rachael, Beekman, Andrew Michael, Cominetti, Marco M. D., O'Connell, Maria A., Chambrier, Isabelle, Cook, Michael J., Marín, María J., Russell, David A., Searcey, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: RSC 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127329/
https://ncbi.nlm.nih.gov/pubmed/34041483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00284d
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