Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

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Vydáno v:RSC Med Chem
Hlavní autoři: Goddard, Zoë Rachael, Beekman, Andrew Michael, Cominetti, Marco M. D., O'Connell, Maria A., Chambrier, Isabelle, Cook, Michael J., Marín, María J., Russell, David A., Searcey, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: RSC 2020
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127329/
https://ncbi.nlm.nih.gov/pubmed/34041483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00284d
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