Potent ex vivo armed T cells using recombinant bispecific antibodies for adoptive immunotherapy with reduced cytokine release

BACKGROUND: T cell-based immunotherapies using chimeric antigen receptors (CAR) or bispecific antibodies (BsAb) have produced impressive responses in hematological malignancies. However, major hurdles remained, including cytokine release syndrome, neurotoxicity, on-target off-tumor effects, reliance...

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Bibliografiske detaljer
Udgivet i:J Immunother Cancer
Main Authors: Park, Jeong A, Santich, Brian H, Xu, Hong, Lum, Lawrence G, Cheung, Nai-Kong V
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2021
Fag:
Immune Cell Therapies and Immune Cell Engineering
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126293/
https://ncbi.nlm.nih.gov/pubmed/33986124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002222
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