The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment

Primary open-angle glaucoma (POAG) constitutes the most common type of glaucoma. Emerging evidence suggests that Endoplasmic Reticulum (ER) stress and the protein kinase RNA-like endoplasmic reticulum kinase (PERK)-mediated Unfolded Protein Response (UPR) signaling pathway play a key role in POAG pa...

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Udgivet i:Int J Mol Sci
Main Authors: Rozpędek-Kamińska, Wioletta, Galita, Grzegorz, Siwecka, Natalia, Carroll, Steven L., Diehl, John Alan, Kucharska, Ewa, Pytel, Dariusz, Majsterek, Ireneusz
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8123501/
https://ncbi.nlm.nih.gov/pubmed/33925820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094494
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