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Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

The CB(1) cannabinoid receptor (CB(1)R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that the allosteric binding site of cannabidiol (CBD) involves residues from the N terminal domain. In order to study the allosteric binding of CBD to...

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Dettagli Bibliografici
Pubblicato in:Molecules
Autori principali: Jakowiecki, Jakub, Abel, Renata, Orzeł, Urszula, Pasznik, Paweł, Preissner, Robert, Filipek, Sławomir
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8122825/
https://ncbi.nlm.nih.gov/pubmed/33922473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26092456
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