Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

Chemotherapy remains the standard of care for most cancers worldwide, however development of chemoresistance due to the presence of the drug-effluxing ATP binding cassette (ABC) transporters remains a significant problem. The development of safe and effective means to overcome chemoresistance is cri...

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Publicado no:Nat Commun
Main Authors: Giddings, Emily L., Champagne, Devin P., Wu, Meng-Han, Laffin, Joshua M., Thornton, Tina M., Valenca-Pereira, Felipe, Culp-Hill, Rachel, Fortner, Karen A., Romero, Natalia, East, James, Cao, Phoebe, Arias-Pulido, Hugo, Sidhu, Karatatiwant S., Silverstrim, Brian, Kam, Yoonseok, Kelley, Shana, Pereira, Mark, Bates, Susan E., Bunn, Janice Y., Fiering, Steven N., Matthews, Dwight E., Robey, Robert W., Stich, Domink, D’Alessandro, Angelo, Rincon, Mercedes
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121950/
https://ncbi.nlm.nih.gov/pubmed/33990571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23071-6
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