PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment

The coinhibitory receptor, PD-1, is of major importance for the suppression of T cell activation in various types of immune responses. A high-resolution imaging study showed that PD-1 forms a coinhibitory signalosome, “PD-1 microcluster”, with the phosphatase, SHP2, to dephosphorylate the TCR/CD3 co...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Takehara, Tomohiro, Wakamatsu, Ei, Machiyama, Hiroaki, Nishi, Wataru, Emoto, Katsura, Azuma, Miyuki, Soejima, Kenzo, Fukunaga, Koichi, Yokosuka, Tadashi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121797/
https://ncbi.nlm.nih.gov/pubmed/33990697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02111-3
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