Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice

OBJECTIVES: To analyse the peptidomics of mouse enteroendocrine cells (EECs) and human gastrointestinal (GI) tissue and identify novel gut derived peptides. METHODS: High resolution nano-flow liquid chromatography mass spectrometry (LC–MS/MS) was performed on (i) flow-cytometry purified NeuroD1 posi...

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Udgivet i:Peptides
Main Authors: Galvin, Sam G., Larraufie, Pierre, Kay, Richard G., Pitt, Haidee, Bernard, Elise, McGavigan, Anne K., Brant, Helen, Hood, John, Sheldrake, Laura, Conder, Shannon, Atherton-Kemp, Dawn, Lu, Van B., O’Flaherty, Elisabeth A.A., Roberts, Geoffrey P., Ämmälä, Carina, Jermutus, Lutz, Baker, David, Gribble, Fiona M., Reimann, Frank
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science Inc 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121762/
https://ncbi.nlm.nih.gov/pubmed/33744371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2021.170532
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