The Comparison of Plasma and Cerebrospinal Fluid R(−)- and S(+)-Flurbiprofen Concentration After Intravenous Injection of Flurbiprofen Axetil in Human Subjects

Background: Flurbiprofen axetil is a prodrug that releases the active substance through enzymatic removal of the ester moiety. It is formulated through encapsulation in a lipid microsphere carrier, and widely used to treat perioperative pain. Here, we studied the distribution of R (−)- and S (+)-flu...

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Bibliografiska uppgifter
I publikationen:Front Pharmacol
Huvudupphovsmän: Yao, Han, Luo, Xingxian, Zhang, Hong, An, Haiyan, Feng, Wanyu, Feng, Yi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2021
Ämnen:
Pharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120306/
https://ncbi.nlm.nih.gov/pubmed/33995057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.646196
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