P-selectin deficiency promotes liver senescence in sickle cell disease mice

Sickle cell disease (SCD) is caused by a homozygous mutation in the β-globin gene, which leads to erythrocyte sickling, vasoocclusion, and intense hemolysis. P-selectin inhibition has been shown to prevent vasoocclusive events in patients with SCD; however, the chronic effect of P-selectin inhibitio...

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Vydáno v:Blood
Hlavní autoři: Vats, Ravi, Kaminski, Tomasz W., Ju, Eun-Mi, Brzoska, Tomasz, Tutuncuoglu, Egemen, Tejero, Jesús, Novelli, Enrico M., Sundd, Prithu, Pradhan-Sundd, Tirthadipa
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2021
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120139/
https://ncbi.nlm.nih.gov/pubmed/33619560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009779
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