Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice

CRISPR-based transcriptional activation is a powerful tool for functional gene interrogation; however, delivery difficulties have limited its applications in vivo. Here, we created a mouse model expressing all components of the CRISPR-Cas9 guide RNA-directed Synergistic Activation Mediator (SAM) fro...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Hunt, Charleen, Hartford, Suzanne A., White, Derek, Pefanis, Evangelos, Hanna, Timothy, Herman, Clarissa, Wiley, Jarrell, Brown, Heather, Su, Qi, Xin, Yurong, Voronin, Dennis, Nguyen, Hien, Altarejos, Judith, Crosby, Keith, Haines, Jeffery, Cancelarich, Sarah, Drummond, Meghan, Moller-Tank, Sven, Malpass, Ryan, Buckley, Jacqueline, del Pilar Molina-Portela, Maria, Droguett, Gustavo, Frendewey, David, Chiao, Eric, Zambrowicz, Brian, Gong, Guochun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119962/
https://ncbi.nlm.nih.gov/pubmed/33986266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22932-4
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