Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice

CRISPR-based transcriptional activation is a powerful tool for functional gene interrogation; however, delivery difficulties have limited its applications in vivo. Here, we created a mouse model expressing all components of the CRISPR-Cas9 guide RNA-directed Synergistic Activation Mediator (SAM) fro...

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Publicado no:Nat Commun
Main Authors: Hunt, Charleen, Hartford, Suzanne A., White, Derek, Pefanis, Evangelos, Hanna, Timothy, Herman, Clarissa, Wiley, Jarrell, Brown, Heather, Su, Qi, Xin, Yurong, Voronin, Dennis, Nguyen, Hien, Altarejos, Judith, Crosby, Keith, Haines, Jeffery, Cancelarich, Sarah, Drummond, Meghan, Moller-Tank, Sven, Malpass, Ryan, Buckley, Jacqueline, del Pilar Molina-Portela, Maria, Droguett, Gustavo, Frendewey, David, Chiao, Eric, Zambrowicz, Brian, Gong, Guochun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119962/
https://ncbi.nlm.nih.gov/pubmed/33986266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22932-4
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