Efficacy and Safety of Methylnaltrexone for the Treatment of Opioid-Induced Constipation: A Meta-analysis of Randomized Controlled Trials

INTRODUCTION: Opioid-induced constipation (OIC) is a distressing side effect during opioid analgesia and is mainly mediated by gastrointestinal μ-opioid receptors. Methylnaltrexone, a peripheral μ-opioid receptor antagonist with restricted ability to cross the blood–brain barrier, may alleviate OIC...

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Bibliographic Details
Published in:Pain Ther
Main Authors: Zhang, Ying-Ying, Zhou, Rong, Gu, Wan-Jie
Format: Artigo
Language:Inglês
Published: Springer Healthcare 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119523/
https://ncbi.nlm.nih.gov/pubmed/33575953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40122-021-00237-0
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