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Targeting ZNF410 as a potential β-hemoglobinopathy therapy
The nucleosome remodeling and deacetylase (NuRD) complex is a chromatin modifier and plays a key role in the switch from fetal to adult hemoglobin (Hb). In a new study, Vinjamur et al. identify a fetal Hb repressor, ZNF410, which does not bind directly to the γ-globin promoter but acts via its highl...
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| Publicado no: | Nat Genet |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8119367/ https://ncbi.nlm.nih.gov/pubmed/33859418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00817-y |
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